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"Quienes" is a form of "quienes", a pronoun which is often translated as "who". "Los que" is a phrase which is often translated as "the ones that". Learn more about the difference between "quienes" and "los que" below.
quienes()
A pronoun is a word that stands in for a noun (e.g., she).
pronoun
a. who
Ellos son quienes siempre me han apoyado.They're the ones who have always been supportive.
b. whom
Ellos son los chicos con quienes toco los fines de semana.They're the guys with whom I play on the weekends.
a. whoever
Felicito a quienes hayan participado en el concurso.Congratulations to whoever participated in the contest.
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los que
A phrase is a group of words commonly used together (e.g., once upon a time).
phrase
a. the ones that
¿Ves esos trofeos? Son los que gané el año pasado.Do you see those trophies over there? Those are the ones that I won last year.
b. the ones who (people)
Mario y Armando son los que organizaron la fiesta.Mario and Armando are the ones who organized the party.
c. those (people)
Los que lleguen temprano tendrán un aperitivo.Those who arrive early will get an appetizer.
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